1. Sources and Habitation
Diosmin is a chemical found in citrus fruits and Scrophularia nodosa, it is also a semisynthetic drug (modified hesperidin), a member of the flavonoid family.
It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin. Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.
2. Descriptions and Specifications of Product
Plant original: Scrophularia nodosa.
Specifications: 98.0% Diosmin Test by HPLC
Molecular Formula: C28H32O15
Molecular Mass: 608.54
CAS NO: 520-27-4
3. Indications and Uses
Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyperpressure.
Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.
Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe.
Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis),and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, and to protect against livertoxicity. It is often taken in combination with hesperidin, another plantchechemical.
4. Safety Concerns
Caution needed for pregnant and breastfeeding women. Side-effects: Stomach and abdominal pain, diarrhea, and headache.
5. Dosage Information
The recommended dose is 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin twice daily for 3 days.
| Items||Specification|| Results|| Remark|
|Extraction method||Ethanol & Water||Complies|| |
|Carriers Used||None||Complies|| |
|Solubility||Un-soluble in water||Complies|| |
|Particle size||100% through 80 mesh||Complies||80 Mesh Screen|
|Heavy Metals (as Pb)||≤10 mg/kg||Complies||GB/T 5009.74|
|Pb||≤1 mg/kg||Complies||GB/T 5009.75|
|As||≤1 mg/kg||Complies||GB/T 5009.76|
|Total Bacteria||≤10,000CFU/g||Complies||GB/T 4789.2|
|Yeast & Molds||≤300CFU/g||Complies||GB/T 4789.15|
|Coliform bacteria/E.Coli ||Absent||Complies||GB/T 4789.3|
| Shelf life||24 months when properly stored. Tightly sealed in a clean, cool, dry place. Keep away from strong, direct light.|
|Conclusion||Complies with specification|