1. Sources and Habitation
Berberine Hydrochloride is an alkaloid derived from Chinese goldthread, bark of cork tree and other plants. It can be also synthesized in artificial method. It is used as raw material to make preparations, which are usually administered the treatment of intestinal infections and bacillary dysentery. Recently usage of anti-arrhythmic was found.
2.Descriptions and Specifications of ProductSpecifications: 98.0% Berberine hydrochloride Test by HPLC
Plant original: Berberis vulgaris
Molecular Formula: C20H18ClNO4·2H2O
Molecular Mass: 407.85
CAS No: 633-65-8
3. Indications and Uses
As a traditional medicine or dietary supplement, berberine has showed some activity against fungal infections, Candida albicans, yeast, parasites, and bacterial/viral infections.Berberine seems to exert synergistic effects with fluconazole even in drug-resistant Candida albicans infections. Some research has been undertaken into possible use against MRSA infection; Berberine is considered an ineffective antibiotic.However, when applied in vitro and in combination with methoxyhydnocarpin, an inhibitor of multidrug resistance pumps, berberine inhibits growth of Staphylococcus aureus; Berberine is a component of some eye drop formulations. There is some evidence that it is useful in the treatment of trachoma,and it has been a standard treatment for leishmaniasis.Berberine prevents and supresses proinflammatory cytokines, E-selectin, and genes, and increases adiponectin expression which partly explains its versatile health effects. Berberine is a nucleic acid-binding isoquinolone alkaloid with wide potential therapeutic properties.
4. Safety Concerns
Adverse reaction for oral administration is less nausea, vomiting, rash, fever, disappeared after drug withdrawal.
5. Dosage Information
Berberine was administered orally for 3 days or 1 week at a dosage of 7.5 or 15 mg/kg/day.
Tissue damage scores, body weight, colon wet weight, and colon wall thickness were measured, and myeloperoxidase activity in colon tissue was also examined. Histological lesions, morphological damage, and myeloperoxidase activity were reduced after 1 week of treatment with berberine at a dosage of 15 mg/kg/day.