1. Sources and Habitation
Citrus aurantium L, belonging to the family Rutaceae, is widely distributed in China. Zhishi, the Chinese traditional name for Citrus aurantium, has long been a folk medicine in traditional Chinese medicine (TCM)to improve indigestion and help stimulate the Qi (energy force). It also has been a folk remedy in Italy since the 16th century for fevers like malaria and as an antiseptic. Recent studies have confirmed that Zhishi, replacing Ma Huang, can be used for treatment of obesity without the negative cardiovascular side effect
2. Descriptions and Specifications of Product
Character: NO-Irradiated Products
Content Specifications: 90%, 92%, 95%, 98% Hesperidin Test by HPLC
Molecular Formula: C28H34O15
Molecular Mass: 610.56
CAS No: 520-26-3
3. Indications and Uses
Hesperidin is a flavanone glycoside (flavonoid) found abundantly in citrus fruits. Its aglycone form is called hesperetin.Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition it contributes to the integrity of the blood vessels.Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has antiinflammatory effects.. Hesperidin is also a sedative, possibly acting through opioid or adenosine receptors.
Some in vitro results applied only to the aglucone form. Hesperidin also showed the ability to penetrate the blood brain barrier in an in vitro model.
4. Safety Concerns
Hesperidin is possibly safe for most people when used for less than three months. Side effects include stomach pain and upset, diarrhea, and headache.Do not use hesperidin if You are pregnant or breast-feeding.
5. Dosage Information
The following doses have been studied in scientific research: For the treatment of hemorrhoids inside the anus: 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days. For preventing the return of hemorrhoids inside the anus: 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months. For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months.
| Items||Specification|| Results|| Remark|
|Color||Light-Cream Yellow to Gray||Complies||Visual|
|Extraction method||Ethanol & Water||Complies|| |
|Carriers Used||None||Complies|| |
|Solubility||Un-soluble in water||Complies|| |
|Particle size||100% through 80 mesh||Complies||80 Mesh Screen|
|Heavy Metals (as Pb)||≤10 mg/kg||Complies||GB/T 5009.74|
|Pb||≤1 mg/kg||Complies||GB/T 5009.75|
|As||≤1 mg/kg||Complies||GB/T 5009.76|
|Total Bacteria||≤10,000CFU/g||Complies||GB/T 4789.2|
|Yeast & Molds||≤300CFU/g||Complies||GB/T 4789.15|
|Coliform bacteria/E.Coli ||Absent||Complies||GB/T 4789.3|
| Shelf life||24 months when properly stored. Tightly sealed in a clean, cool, dry place. Keep away from strong, direct light.|
|Conclusion||Complies with specification|